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Profile of the exponential function, W ( t ) = 0.67exp(−0.003154( t − 365)) (blue curve) used to estimate the waning rate <t>of</t> <t>the</t> <t>R21/Matrix-M</t> vaccine, assuming waning begins one year post-administration (dashed vertical red line) and reaches near zero within four years.
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Profile of the exponential function, W ( t ) = 0.67exp(−0.003154( t − 365)) (blue curve) used to estimate the waning rate of the R21/Matrix-M vaccine, assuming waning begins one year post-administration (dashed vertical red line) and reaches near zero within four years.

Journal: medRxiv

Article Title: Mathematical assessment of the impact of the R21/Matrix-M vaccine on the control of malaria in children in Burkina Faso

doi: 10.64898/2026.01.25.26344791

Figure Lengend Snippet: Profile of the exponential function, W ( t ) = 0.67exp(−0.003154( t − 365)) (blue curve) used to estimate the waning rate of the R21/Matrix-M vaccine, assuming waning begins one year post-administration (dashed vertical red line) and reaches near zero within four years.

Article Snippet: A more effective vaccine, R21/Matrix-M, developed by the Jenner Institute, University of Oxford and produced by the Serum Institute of India Private Limited (SIIPL) [ ], was approved by the WHO in December of 2023 [ ].

Techniques:

Contour plots of the control reproduction number of the model (E.1), as a function of the steady-state vaccine coverage and vaccine efficacy , for children in Burkina Faso under the age of 3 (i.e., children in Group 1) who received the first dose (only) of the R21/Matrix-M vaccine. (a) no bednet coverage (i.e., c b = ε b = 0), and (b) with bednet usage at baseline levels (i.e., c b = 0.657 and ε b = 0.85). The red curve represents the level curve . The dashed green horizontal line corresponds to , which is the baseline efficacy of the first dose of the R21/Matrix-M vaccine . The dashed black vertical line, drawn through the intersection point of the red curve with the dashed green line, indicate the corresponding vaccine coverage level, , required to achieve the HIT in the targeted group. Parameter values used to generate the contour plots are as given in and .

Journal: medRxiv

Article Title: Mathematical assessment of the impact of the R21/Matrix-M vaccine on the control of malaria in children in Burkina Faso

doi: 10.64898/2026.01.25.26344791

Figure Lengend Snippet: Contour plots of the control reproduction number of the model (E.1), as a function of the steady-state vaccine coverage and vaccine efficacy , for children in Burkina Faso under the age of 3 (i.e., children in Group 1) who received the first dose (only) of the R21/Matrix-M vaccine. (a) no bednet coverage (i.e., c b = ε b = 0), and (b) with bednet usage at baseline levels (i.e., c b = 0.657 and ε b = 0.85). The red curve represents the level curve . The dashed green horizontal line corresponds to , which is the baseline efficacy of the first dose of the R21/Matrix-M vaccine . The dashed black vertical line, drawn through the intersection point of the red curve with the dashed green line, indicate the corresponding vaccine coverage level, , required to achieve the HIT in the targeted group. Parameter values used to generate the contour plots are as given in and .

Article Snippet: A more effective vaccine, R21/Matrix-M, developed by the Jenner Institute, University of Oxford and produced by the Serum Institute of India Private Limited (SIIPL) [ ], was approved by the WHO in December of 2023 [ ].

Techniques: Control